Senior Director, Commercialization Technology Architect

Job Description Position Summary Vertex is entering an exciting phase of commercial diversification. As we expand into new pipeline disease areas and new geographies, we are investing in data, technology, and AI to scale commercial operations globally. The Commercial, Medical and External Affairs Technology team is expanding our capabilities with increased investment in data, platforms, and AI. This role establishes the end-to-end architecture required to scale AI and digital capabilities across the enterprise. The Senior Director, Commercialization Technology Architect is responsible for defining and governing target-state architectures, integration patterns, and platform standards that enable scalable, secure, and compliant AI solutions. This role ensures technologies deployed by Product, Data, and Engineering teams are aligned to enterprise architecture, interoperable across systems, and built for long-term scale. This is a technical architecture leadership role focused on translating business and product direction into production-ready system design, data flows, and platform integration. Key Responsibilities Architecture Strategy & Standards Define and maintain target-state architecture across Commercial and Medical ecosystems Establish reference architectures, design patterns, and engineering standards for AI-enabled systems Govern architecture alignment across CRM, omnichannel, patient services, and enterprise platforms Ensure consistency with enterprise architecture and platform strategies Integration & Data Architecture Own integration patterns and data flows across Salesforce, Veeva, data platforms, and downstream systems Define real-time and batch data architectures, including event-driven patterns and APIs Ensure alignment with enterprise data platforms (e.g., MDM, Snowflake, Databricks) Partner with Data teams to ensure data readiness, lineage, and interoperability Technology & Platform Governance Partners with engineering function and core technology to define standards across cloud and data platforms MDM, Snowflake, Databricks, Snowflake supporting Commercial and Medical affairs domains Lead architecture decisions for build vs. buy vs. partner solutions Establish environment, deployment, and DevOps architecture patterns within the Commercial and Medical affairs domains Maintain architecture documentation for scalability, reuse, and audibility Security, Risk & Compliance Ensure architectures meet SOX, GxP, privacy, and security requirements Define patterns for observability, audibility, and controls in AI systems Partner with InfoSec, Legal, Privacy, and Quality to embed compliance by design Delivery Enablement Partner with Product Management, Engineering, and Data teams to translate product requirements into executable architectures Provide hands-on guidance to ensure solutions are production-ready and aligned to standards Serve as final architecture authority for design reviews and major platform decisions Knowledge & Skills Deep expertise in enterprise architecture, solution design, and distributed systems Strong experience with CRM and commercial platforms (Salesforce, Veeva) Proven ability to design complex integrations and data architectures at scale Hands-on experience with cloud and data warehouse platforms (AWS, Azure, Snowflake, etc...) and modern data stacks Experience designing systems incorporating AI/ML and LLM-based capabilities Strong understanding of AI architectures (e.g. MCP) Expertise in security, compliance, and regulated environments (SOX, GxP) Ability to translate complex architecture into clear guidance for engineering teams Education & Experience Bachelor’s or Master’s degree in Computer Science, Engineering, or related field 12+ years of experience in enterprise architecture or solution architecture roles Experience in pharma, biotech, or regulated healthcare environments strongly preferred Proven track record delivering enterprise-scale platform and integration architecture Experience working across Commercial, Medical, or patient services systems At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $228,000 - $342,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.