Senior Director, Immunology

Job Description General Summary: The Senior Director, Immunology will oversee multiple research programs and initiatives that support the research and development of the Vertex portfolio, and collaborate closely with manufacturing, process and analytical development colleagues to support the development of advanced therapies. This role will be responsible for driving execution of current projects and leading the identification of new opportunities. This individual will help define and drive immunology research strategies, lead the development of novel immunomodulatory approaches to enable transformative advances in allogeneic transplantation, and provide scientific leadership across a diverse portfolio of discovery and development programs. Through deep scientific expertise, strategic vision, and exceptional communication and influencing skills, this role will shape research direction, guide critical investment and development decisions, and foster cross-functional collaboration to advance the company's cell and genetic therapy pipeline. This is a Boston based ONSITE position. Responsibilities Serve as Research Program Team Lead for 2+ programs driving cross-functional collaboration and alignment to achieve program goals Develop strategy and build capabilities to advance novel, next gen drug discovery in T1D Provide scientific, strategic, and organizational leadership for immunology research and drug discovery programs supporting the cell and genetic therapy portfolio. Develop and execute innovative immunomodulatory and translational immunology strategies to advance allogeneic transplantation and other immune-mediated therapeutic opportunities. Lead cross-functional teams to identify, validate, and advance novel therapeutic targets and candidates from discovery through development while ensuring timely, high-quality execution and communication of research results. Shape research and portfolio strategy through deep immunology expertise, data-driven conclusions, emerging scientific advances, and balanced pursuit of innovation against defined project objectives. Build and maintain productive collaborations across internal functions and with external academic, clinical, industry, and pharma partners. Manage group resources, budgets, hiring, staff activities, and goal setting to align scientific capabilities and personnel priorities with department and corporate objectives. Mentor and develop high-performing scientists while fostering scientific rigor, technical excellence, ethical publication and patenting practices, and clear communication across the organization. Knowledge & Skills Deep scientific expertise in immunology, immunology-driven drug discovery, and translational science, including biomarker development and clinical application of preclinical findings. Proven ability to advance therapeutic programs from target discovery through candidate selection across modalities, including cell and genetic therapies, biologics, small molecules, and nucleic acid-based medicines. Strong scientific judgment and strategic thinking to shape portfolio strategy, guide investment decisions, and identify productive in vivo, ex vivo, and translational approaches. Experience leading cross-functional and matrixed teams to execute complex experiments, communicate results effectively, and influence stakeholders across the organization. Expertise in pharmacological and immunological models of autoimmunity, allo-transplantation, type 1 diabetes, allo-islet transplantation, and immune response analysis in murine, non-human primate, and human systems. Advanced technical expertise in cellular and molecular immunology methods, such as multicolor flow cytometry, ex vivo immune cell culture and functional assays, immunohistochemistry, immunophenotyping, ELISA, cell sorting, RNA-seq, epigenetics, and complex dataset analysis. Exceptional communication, presentation, and leadership skills, with demonstrated ability to mentor talent, develop teams, and represent high standards of scientific integrity and organizational practice. Required Education & Experience PhD/MD (or equivalent degrees) in immunology, molecular biology, cell biology, molecular pathology, or related disciplines 12+ years of industry or equivalent experience in Immunology Experience in supervising others work, leadership of cross functional teams and contributing to discovery and development programs to IND, FIM and PoC. #LI-KM1 #LI-Onsite At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $237,900 - $356,900 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Onsite Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.