Manager, Disease Strategy Finance

Job Description The Manager, Disease Strategy Finance is a key member of Vertex's Disease Strategy Finance Team, providing financial and strategic insights to inform Disease Strategy Teams (“DSTs”) on key decisions. This role will work closely with Directors on the DST Finance team to conduct financial modeling, forecasting, and scenario-based valuations. The Manager, Disease Strategy Finance will also play a critical role in creation of the Annual Budget, Long-Term Plan (LRP), and other financial forecasts in collaboration with colleagues. The role will partner closely with members of the global COFO organization, including finance teams supporting R&D, Biopharmaceutical Sciences and Manufacturing, Corporate, and Commercial. This role offers an opportunity to make a lasting impact by driving profitable growth while creating transformative medicines for people with serious diseases. Position Summary: Reporting to the Senior Director, Finance – Disease Strategy Teams, the Manager is a key member of Vertex’s Strategy Finance team and the global FP&A organization. This role will lead financial analysis required to inform Disease Strategy Teams (“DSTs”) on key decisions. Financial analyses will include financial modeling, forecasting, and scenario-based valuations. The Manager FP&A, Strategy Finance will also play a critical role in creating the Annual Budget, Long-Term Plan (LRP), and other financial forecasts. The role will be primary lead for preparation of collaboration financials for both internal and external partner reporting. The role will partner closely with members of the global CFO organization, including finance teams supporting R&D, Biopharmaceutical Sciences and Manufacturing, and Commercial. This role offers an opportunity to make a lasting impact by driving profitable growth while creating transformative medicines for people with serious diseases. Key Responsibilities: Prepare a wide range of financial analyses to inform DST decisions on investments. Lead preparation of alliance/collaboration financials for revenue/cost sharing in accordance with co-development/co-commercialization contract terms. Develop and maintain financial models covering all aspects of biopharmaceutical research, development, manufacturing, and commercialization. Provide Strategy Finance input into regular financial planning processes (Annual Budget, Forecasts, Long-Range Plan), for assigned Disease Areas. Manage Disease Area P&Ls for assigned DSTs, including ensuring consistent presentation of DST finances across Vertex, explanation of variances vs. forecasts, identification of risks/uncertainties, and opportunities for mitigation. Prepare a wide range of presentations for cross-functional stakeholders and senior leaders. Collaborate throughout CFO organization to identify and deliver on process improvement opportunities. Qualifications: B.S. Degree in Finance, Economics, or related quantitative/analytical field; MBA preferred. 5+ years of relevant finance and industry experience - Biotechnology/Pharmaceutical industry experience strongly preferred. Experience with biopharma alliance/collaboration accounting preferred though not required. Understanding of biopharmaceutical drug research, development, manufacturing, and commercialization required. Exceptional analytical and financial skills to evaluate a broad range of financial questions – especially valuation, ROI/ROIC, and complex multi-disciplinary business decisions. Experience with Excel and PowerPoint; Experience with Hyperion (or another multidimensional database), business intelligence or visualization tools a plus. Proficient business acumen, judgment and knowledge of the company’s markets/products and industry trends. Strong communication skills, both written and verbal, and an eagerness to collaborate with colleagues (within or outside of finance) in sharing insights and learnings. Must be able to work well with senior leaders, peers, and junior team members. Possesses a high degree of attention to detail and ownership over work product with the flexibility to adapt to change. #HYBRID #LI-MF1 At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $116,000 - $174,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.